Rhinovirus
Microbiology > Virology > RNA viruses > Single Stranded RNA viruses > Picornavirus
- Structure
- Part of the Picornavirus family
- Small virus (20-30 nm)
- Naked ssRNA+, icosahedral capsid
- Pathobiology
- Transmitted by respiratory droplets
- Enters cell by attaching ICAM-1
- Present on many cells such as epithelial, fibroblast, B-lymphoblast cells
- Acid labile
- All other viruses in the picornavirus family are acid stabile
- Grows best at 33-35˚C
- Infects the upper respiratory tract because it is cooler than body temperature
- Able to survive outside the human body for up to 3 hours
- Multiple serotypes (>100)
- Previous infection does not provide immunity from subsequent infections
- Hard to develop a vaccine
- Epidemiology
- Transmitted through direct contact, fomites, and respiratory droplets
- Typically see cases in the Autumn or winter
- Lab Diagnosis
- Disease Manifestations
- Common Cold
- Non-specific URI, rhinorrhea, and nasal obstruction
- Therapy: supportive care
- Prevention: washing hands
- Differential diagnosis: Other causes of the common cold
- Rhinovirus
- Coronavirus
- Adenovirus
- Influenza C virus
- Coxsackie virus
Related conceptscommon cold