Herpes simplex type I (HSV1) - MegaMicro

Go to content

Main menu:

Herpes simplex type I (HSV1)

Microbiology > Virology > DNA viruses > Herpes viruses
Herpes Simplex - type I  (HSV-1 or HSV1)

·         Person-to-person via contact inoculation or droplet infection
·         Risk factors: increased age, low socioeconomic status
·         80% of people of 30 are seropositive!

Clinical presentation
·         The vast majority of people are asymptomatic, 9% have minor disease and 1% have serious disease on primary infection, including:
o   Gingavostomatitis (tons of blisters around and in the mouth, on lips), keratoconjunctivitis, genital herpes, eczema herpiticum, necrotizing focal encephalitis, disseminated herpes, Whitlow (infection of the distal phalanges of hand – very painful) and inoculation herpes, neonatal herpes, Kaposi’s Varicelliform Eruption (eczema herpeticum: blisters all over scalp, face and neck), dendritic keratitis (deep stromal ulcers of the eye)
·         That 1% may have reactivation disease that includes fever blisters, inoculation (Whitlow), keratoconjunctivitis, necrotizing focal encephalitis

·         Clinical presentation: vesicular eruption, etc
·         Antigen detection via DFA
·         Exfoliative cytology or histopathology
o   Intranuclear inclusions
o   Multinucleate giant cells
o   Tzanck Smear of vesicle
·         Virus isolation in tissue culture
§ Antibody testing

§ Acyclovir (Valacylovir, Penciclovir)
§ Ganciclovir  and cidofovir effective but not given first-line
§ Foscarnet for resistant virus due to Thymidine Kinase deficient mutants
Related concepts

Copyright 2016. All rights reserved.
Back to content | Back to main menu